Table 1 Top 15 differentially expressed genes (FDR < 0.25) between the infarcted hemisphere and the contralateral healthy hemisphere 2 h after cerebral ischemia induction. Genes that are differentially expressed in all the groups of animals are highlighted in bold. FDR: false discovery rate; logFC: Logarithmic fold change
Young male mice, males | Young female mice, females | Diabetic young male mice, diabetic | Aged male mice, old | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SYMBOL | logFC | P.Value | FDR | SYMBOL | logFC | P.Value | FDR | SYMBOL | logFC | P.Value | FDR | SYMBOL | logFC | P.Value | FDR |
CCL3 | 2.4958 | 1.73E-15 | 8.80E-12 | ATF3 | 1.4557 | 1.42E-06 | 0.00284 | HSPA1A | 2.4544 | 1.02E-09 | 5.17E-06 | NPAS4 | 2.9274 | 1.53E-08 | 7.75E-05 |
FOSB | 1.9774 | 7.77E-12 | 1.58E-08 | PTGS2 | 1.5976 | 1.76E-06 | 0.00284 | FOS | 2.4266 | 9.29E-09 | 1.63E-05 | CCL3 | 2.0499 | 1.08E-07 | 2.74E-04 |
CCN1 | 1.8493 | 1.10E-11 | 1.58E-08 | CCRL2 | 1.1296 | 2.21E-06 | 0.00284 | CCN1 | 1.9876 | 9.61E-09 | 1.63E-05 | FOS | 1.6891 | 8.48E-07 | 0.00143 |
FOS | 2.1172 | 1.25E-11 | 1.58E-08 | FOS | 1.5602 | 2.24E-06 | 0.00284 | CCL3 | 2.6185 | 1.55E-08 | 1.97E-05 | IL1A | 1.7778 | 2.60E-06 | 0.00329 |
NPAS4 | 2.6951 | 7.08E-11 | 7.18E-08 | CCL3 | 2.1777 | 2.93E-06 | 0.00298 | FOSB | 2.1383 | 4.27E-08 | 4.33E-05 | PTGS2 | 1.3054 | 5.90E-06 | 0.00599 |
ATF3 | 1.6062 | 1.09E-09 | 9.22E-07 | NPAS4 | 2.2737 | 4.40E-06 | 0.00372 | GADD45G | 1.7414 | 5.81E-08 | 4.91E-05 | FOSB | 1.5304 | 9.64E-06 | 0.00815 |
JUNB | 1.4066 | 2.36E-09 | 1.67E-06 | ADAMTS1 | 1.0314 | 6.65E-06 | 0.00482 | IER2 | 1.2020 | 9.91E-08 | 7.18E-05 | DUSP6 | 0.9922 | 3.29E-05 | 0.02382 |
RGS2 | 1.4974 | 2.80E-09 | 1.67E-06 | CCN1 | 1.3156 | 9.48E-06 | 0.00601 | THBS1 | 1.8039 | 1.14E-07 | 7.22E-05 | HSPA1A | 1.6433 | 7.39E-05 | 0.04390 |
GADD45G | 1.3902 | 2.96E-09 | 1.67E-06 | NR4A1 | 1.0643 | 1.54E-05 | 0.00868 | NPAS4 | 3.1196 | 3.98E-07 | 2.25E-04 | JUN | 0.8117 | 8.45E-05 | 0.04390 |
HSPA1A | 1.5433 | 3.32E-09 | 1.68E-06 | FOSB | 1.5493 | 1.88E-05 | 0.00951 | DUSP6 | 1.1689 | 5.27E-07 | 2.67E-04 | CCL4 | 1.1057 | 8.66E-05 | 0.04390 |
EGR4 | 1.4966 | 8.59E-09 | 3.79E-06 | RND3 | 0.8880 | 2.34E-05 | 0.01079 | NR4A1 | 1.6955 | 7.58E-07 | 3.49E-04 | FKBP11 | -1.0158 | 1.84E-04 | 0.08205 |
NR4A1 | 1.4166 | 8.97E-09 | 3.79E-06 | RGS1 | 1.1871 | 2.88E-05 | 0.01216 | EGR4 | 1.6425 | 9.33E-07 | 3.94E-04 | GM9958 | -0.9378 | 2.12E-04 | 0.08205 |
PTGS2 | 1.3968 | 1.51E-08 | 5.88E-06 | GADD45G | 1.0496 | 3.97E-05 | 0.01547 | RGS2 | 1.3091 | 1.09E-06 | 4.23E-04 | NR4A1 | 1.1258 | 2.21E-04 | 0.08205 |
BTG2 | 1.2922 | 2.79E-08 | 1.01E-05 | DUSP6 | 0.8763 | 4.39E-05 | 0.01547 | JUN | 1.1095 | 1.17E-06 | 4.23E-04 | CCRL2 | 0.9681 | 2.27E-04 | 0.08205 |
EGR2 | 1.3976 | 4.45E-08 | 1.51E-05 | GALNT12 | -1.1040 | 4.58E-05 | 0.01547 | AKAP12 | 0.9770 | 1.51E-06 | 5.10E-04 | CCN1 | 1.2480 | 2.56E-04 | 0.08651 |