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Fig. 5 | BMC Neuroscience

Fig. 5

From: Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion

Fig. 5

MiR-17 is the target of Circ VRK1, and PTEN is the target of miR-17 in HBMVECs. A Circ VRK1 downstream miRNAs predicted by StarBase. B miRNA expression changes in Circ VRK1 downregulated cells by qPCR. C KEGG pathway analysis of miRNA target genes in theStarBase. D The targeting relationship between Circ VRK1 and miR-17, miR-17 and PTEN verified by dual-luciferase assay. E miR-17 and PTEN mRNA expression in HBMVECs by qPCR. F miR-17 and PTEN mRNA expression in brain tissues of mice by RT-qPCR. Error bars represented the mean ± SD from 3 independent experiments or n = 6. Two-way ANOVA was used

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BMC Neuroscience

ISSN: 1471-2202

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