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Fig. 4 | BMC Neuroscience

Fig. 4

From: Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion

Fig. 4

Silencing of Circ VRK1 alleviates brain injury in mice. C57BL/6 mice were modeled with OGD/R and injected with lentiviral vectors harboring Circ VRK1 NC or Circ VRK1 siRNA. A scoring of nerve damage in mice by Zea Longa scores. B the expression of Circ VRK1 in brain tissues of mice examined using PCR. C brain tissue damage in mice by HE staining. D The area of cerebral infarction in mice examined by TTC staining. E Score of CD34 IHC scores in tissues. F Representative pictures of western blotting for VEGF protein expression in brain tissues of mice, and all replicates are presented in the Additional file 1 (images of adequate length are not provided). Error bars represented the mean ± SD (n = 6). One-way (B, D) or two-way ANOVA (A) were used

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