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Fig. 1 | BMC Neuroscience

Fig. 1

From: Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion

Fig. 1

OGD/R treatment decreases HBMVEC viability and upregulates Circ VRK1 expression. A the viability of HBMVECs exposed to OGD for 2 h, 4 h and 8 h detected by CCK8 assay. B The cytotoxicity of HBMVECs exposed to OGD for 2 h, 4 h and 8 h measured by LDH release assay. C circRNA microarray analysis of differentially expressed circRNAs in cells exposed to OGD/R. D circ_0000566 expression changes in HBMVECs exposed to OGD for 2 h, 4 h and 8 h by RT-qPCR. E The genome position and source genes of circ_0000566 queried in circBase. F the localization of Circ VRK1 in HBMVECs determined by subcellular fractionation. G PCR validation of Circ VRK1 siRNA transfection efficiency in HBMVEC. Error bars represented the mean ± SD from 3 independent experiments. Unpaired t test (G) and one-way (A–D) or two-way ANOVA (F) were used

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BMC Neuroscience

ISSN: 1471-2202

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