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Table 2 Diagnostic value of cytokines in SFN

From: Cytokine expression profiles in white blood cells of patients with small fiber neuropathy

Biomarker

AUC (95% CI)

Sensitivity %

Specificity %

Optimal cut-off

IL-2

0.68

70

62

0.69

IL-8

0.69

76

62

0.65

TNF

0.67

52

86

0.73

IL-2 + IL-8

0.78

64

91

0.76

IL-2 + TNF

0.78

54

91

0.81

IL-8 + TNF

0.74

90

48

0.54

IL-2 + IL-8 + TNF

0.81

70

86

0.67

  1. AUC area under the curve, CI confidence interval, IL− interleukin, SFN small fiber neuropathy, TNF tumor necrosis factor-alpha