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Fig. 3 | BMC Neuroscience

Fig. 3

From: Effects of low-doses of methamphetamine on d-fenfluramine-induced head-twitch response (HTR) in mice during ageing and c-fos expression in the prefrontal cortex

Fig. 3

Suppressive effects of varying doses of MA on the mean (± SEM) frequency of HTR induced by d-fenfluramine (5 mg/kg, i.p.) in 20 (MA at 0, 0.1, 0.25, 1 mg/kg, i.p.)-, 30 (MA at 0, 0.1, 0.25, 1, 2.5 mg/kg, i.p.)- and 60 (MA at 0, 1, 2.5, 5 mg/kg, i.p.)-day old mice. Varying doses of MA inhibited d-fenfluramine-induced HTR in a dose-dependent manner across the age-range tested. Compared to corresponding age-matched vehicle-pretreated control group, significant reductions were observed at 1 mg/kg in 20-day old mice, at 1 and 2.5 mg/kg in 30-day old mice, at 2.5 and 5 mg/kg in 60-day old mice, respectively. **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. vehicle injection; Kruskal–Wallis non-parametric one-way ANOVA followed by Dunn’s test. n = 5 − 9 in each group. Data are presented as means ± SEM

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