Transcranial direct current stimulation combined with amantadine in repetitive mild traumatic brain injury in rats

Table 2 Behavioral and MEP test results of each groups

	Control			Amantadine			tDCS			Combination
	Pre-mTBI	Post-mTBI	Post-treatment	Pre-mTBI	Post-mTBI	Post-treatment	Pre-mTBI	Post-mTBI	Post-treatment	Pre-mTBI	Post-mTBI	Post-treatment
Duration on rotarod (sec)	141.15 ± 10.06	118.95 ± 7.72	121.15 ± 9.88	133.50 ± 8.66	100.80 ± 11.41	131.55 ± 16.95	147.30 ± 4.88	102.75 ± 16.72	150.30 ± 16.10^b	124.50 ± 13.65	115.90 ± 14.65	164.05 ± 18.64^b
Maximal speed on rotarod (rpm)	21.00 ± 1.202	18.00 ± 0.99	17.80 ± 1.28	20.20 ± 1.245	15.40 ± 1.66	20.00 ± 2.13	22.40 ± 0.884	15.40 ± 2.39	22.20 ± 2.220^b	18.80 ± 1.867	17.60 ± 2.06	24.20 ± 2.641^b
Object ratio (%)	217.88 ± 60.17	94.98 ± 19.39	81.79 ± 11.92	170.40 ± 42.86	104.30 ± 21.66	156.89 ± 22.07	201.19 ± 39.02^b	119.47 ± 11.81	149.11 ± 14.54	139.76 ± 17.98	59.98 ± 11.62	159.55 ± 14.82^b
Latency of MEP (ms)	4.01 ± 0.17	5.20 ± 0.36	5.34 ± 0.25	4.29 ± 0.22	5.13 ± 0.18	5.50 ± 0.21	4.97 ± 0.22	4.97 ± 0.28	4.74 ± 0.23	4.59 ± 0.19	4.85 ± 0.26	4.56 ± 0.20
Amplitude of MEP (μV)	203.70 ± 33.75	92.40 ± 13.92	69.80 ± 13.27	133.70 ± 31.23	81.30 ± 10.52	94.60 ± 11.43	262.10 ± 52.32	131.40 ± 24.22	215.00 ± 30.23	180.20 ± 21.10	100.70 ± 11.00	123.60 ± 13.90^a

The duration and maximal speed on rotarod were significantly improved in the combination and tDCS group. The object ratio of the novel object test was significant increased in the combination group and amantadine groups. Combination group showed significantly increased amplitude of MEP after treatments
^a ≤ 0.05 significant difference between post-mTBI and post-treatment by Wilcoxon signed rank test
^b ≤ 0.01 significant difference between post-mTBI and post-treatment by Wilcoxon signed rank test

ISSN: 1471-2202