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Fig. 3 | BMC Neuroscience

Fig. 3

From: Human iPSC-derived neural stem cells with ALDH5A1 mutation as a model of succinic semialdehyde dehydrogenase deficiency

Fig. 3

The cDNA sequencing of ALDH5A1-mutated iPSC lines (p.L243_S245del and p.A244_Q246del) and the wild-type. A The letters F1, R1, F2-1, F2-2, R2, F3, and R3 indicate the location of each primer for cDNA sequencing. B Comparison of the cDNA sequencing results among two mutant cell lines and the wild type. The mRNA splicing variant detected in L243_S245del results in the deletion of 12 bases in exon 5 and the mRNA splicing variant detected in p.A244_Q246del mutant lacks 545 bases encompassing exons 4 to 6 and parts of exons 3 and 7

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BMC Neuroscience

ISSN: 1471-2202

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