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Fig. 4 | BMC Neuroscience

Fig. 4

From: Trait anxiety is related to Nx4’s efficacy on stress-induced changes in amygdala-centered resting state functional connectivity: a placebo-controlled cross-over trial in mildly to moderately stressed healthy volunteers

Fig. 4

RSFC and TA correlate. Resting state functional connectivity(RSFC) between right amygdala and pregenual anterior cingulate cortex (pgACC)/ventro-medial prefrontal cortex (vmPFC) and its correlation with trait anxiety (TA) for placebo (red) and Nx4 (blue) condition for all 33 participants. A No significant differences were observed between pre-stress resting state (RS1) and post-stress resting state (RS2) for placebo nor for Nx4 conditions. Data are given as individual dot blots with meanstandard error of mean. B Stress-induced RSFC changes (contrast \(RS2>RS1\)) between right amygdala and pgACC/vmPFC is positively correlated with TA for placebo and negatively correlated with TA for Nx4 condition. Each dot in the scatter plot represents data from one participant. Dashed lines indicate 95% confidence interval of the linear model fit. Normative average TA for the study population is indicated as a horizontal dashed black line

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