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Fig. 4 | BMC Neuroscience

Fig. 4

From: Cholesterol efflux regulator ABCA1 exerts protective role against high shear stress-induced injury of HBMECs via regulating PI3K/Akt/eNOS signaling

Fig. 4

Inhibition of PI3K/Akt/eNOS counteracts HSS-induced functional alterations in HBMECs. A Effect of PI3K/Akt/eNOS inhibitors on the viability of HBMECs under HSS treatment. B Effect of PI3K/Akt/eNOS inhibitors on the caspase3/7 activity in HBMECs under HSS treatment. C Effect of PI3K/Akt/eNOS inhibitors on the apoptosis of HBMECs under HSS treatment as determined by flow cytometry. D Effect of PI3K/Akt/eNOS inhibitors on ROS production in HBMECs under HSS treatment. E Effect of PI3K/Akt/eNOS inhibitors on NO production in HBMECs under HSS treatment. F Effect of PI3K/Akt/eNOS inhibitors on the release of inflammatory cytokines in HBMECs under HSS treatment. G Effect of PI3K/Akt/eNOS inhibitors on the mRNA levels of IL-1β, IL-6, MCP-1 and TNF-α as determined by qRT-PCR in HBMECs under HSS treatment. H Effect of PI3K/Akt/eNOS inhibitors on the migration of HBMECs under HSS treatment. ⁎⁎p < 0.01 versus control

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