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Fig. 1 | BMC Neuroscience

Fig. 1

From: Mechanism of LSD1 in oxygen-glucose deprivation/reoxygenation-induced pyroptosis of retinal ganglion cells via the miR-21-5p/NLRP12 axis

Fig. 1

OGD/R induces pyroptosis of RGCs and upregulates LSD1. RGC-5 cells received OGD/R treatment. A: RGC-5 cell viability was detected via the CCK-8 method; B: The concentrations of IL-1β and IL-18 were examined via ELISA; C: The mRNA levels of LSD1 and Caspase 1 in RGC-5 cells were determined via RT-qPCR; D: The protein levels of NLRP3, GSDMD-N, cleaved-Caspase1, and LSD1 in RGC-5 cells were examined via Western blot analysis. Each cell experiment was performed in triplicate; measurement data were presented as mean ± standard deviation (SD); data in panel A were analyzed via the t-test; data in panels B-D were analyzed via two-way ANOVA, followed by Tukey’s multiple comparison test; *p < 0.05

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