Fig. 9
From: Morphine-induced changes in the function of microglia and macrophages after acute spinal cord injury
Quantification of β-arrestin pathway protein, Dynorphin, and Pro-Dynorphin in CD11b+ cells from center of lesion 30-min after 3 days of drug administration. Morphine administration significantly increases the expression of β-arrestin (A) and ERK 1 (C) in contused rats compared to their saline-treated counterparts. Morphine administration significantly increases the expression of pro-dynorphin (E) and dynorphin (F) in contused rats compared to their saline-treated counterparts. There was a trend towards higher expression of p38 MAPK (B) and ERK 2 (D) with morphine treatment but no significant effects were found. Loading control: protein extracted from CD11b+ cells from spinal cord tissue from sham rats treated with saline. Results shown as Mean ± S.E.M. *p < 0.05, n = 6