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Fig. 8 | BMC Neuroscience

Fig. 8

From: High-frequency repetitive transcranial magnetic stimulation (rTMS) protects against ischemic stroke by inhibiting M1 microglia polarization through let-7b-5p/HMGA2/NF-κB signaling pathway

Fig. 8

rTMS stimulated MCM reduced infarct volumes and promoted functional recovery in MCAO mice, but weaken by let-7b-5p antagomir. Immediately after reperfusion and at 3 days post reperfusion, the MCAO mice received retroorbital intravenously injection of indicated MCM. At 7 days post reperfusion, ischemic regions were detected by TTC staining. a Representative image of TTC staining in the indicated groups. b Quantitative analysis of infarct volume. c The neurological deficit was evaluated by modified Neurological Severity Score (mNSS). n = 8 animals per group. Data are expressed as mean ± SD; **P < 0.01, ***P < 0.001, ns no significance

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BMC Neuroscience

ISSN: 1471-2202

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