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Fig. 8 | BMC Neuroscience

Fig. 8

From: Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1G93A ALS mouse model

Fig. 8

Cell specific location of IL-1β in the lumbar spinal cord. Representative images of double immunofluorescence staining for IL-1β with NeuN, GFAP, or Iba1 are shown. At 60 d, increased expression of IL-1β was observed in the neuronal cytoplasm of ventral horn spinal cord of ALS mice, and low expression was found in CON mice a. Besides NeuN+/IL-1β+ double positive cells, dramatic co-localization of IL-1β with activated GFAP+ astrocytes and Iba1+ microglia in transgenic ALS mice were observed from 95 to 122 d b, c, d. Arrows indicate double-labelled cells. Scale bar 50 μm

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