Fig. 7
Depletion of intracellular Ca2+, CRF could not trigger MLI-PC LTP. A Upper: Representative cell-attached recording traces showing air-puff stimulation (10 ms, 60 psi; arrows)-evoked responses in a cerebellar PC before (Pre) and after (post) delivering 1 Hz (240 pulses) stimulation in the presence of a mixture of AM251 (5 µM) + cyclopiazonic acid (CPA, 100 µM) + CRF (100 nM). B Summary of data showing the time course of normalized P1 amplitude before and after delivery of 1 Hz facial stimulation (arrow head) in treatment with a mixture of AM251 + CPA + CRF. C Bar graph with individual data showing the normalized amplitude of P1 before (Pre), after (Post) delivery of 1 Hz stimulation. D Mean (± S.E.M.) with individual data showing the normalized pause of simple spike firing before (Pre), after (Post) delivery of 1 Hz stimulation. #P < 0.05 vs. baseline (Pre) of AM-251 + CRF; *P < 0.05 vs. post of AM-251 + CRF. n = 8 mice in each group