Fig. 2

Blockade of CRF-R1, CRF failed to prevent facial stimulation-evoked MLI-PC LTD. A Upper: Representative cell-attached recording traces showing air-puff stimulation (10 ms, 60 psi; arrows)-evoked responses in a cerebellar PC before (Pre) and after (post) delivering 1 Hz (240 pulses) facial stimulation in the presence of a mixture of BSM (200 nM) and CRF (100 nM). B Summary of data showing the time course of normalized P1 amplitude before and after delivery of 1 Hz facial stimulation (arrow head) in the presence of the mixture. C Bar graph with individual data showing the normalized amplitude of P1 before (Pre), after (Post) delivery of 1 Hz stimulation. D Mean (± S.E.M.) with individual data showing the normalized pause of simple spike firing before (Pre), after (Post) delivery of 1 Hz stimulation. ^#P < 0.05 versus Pre of BSM + CRF; *P < 0.05 versus post of CRF. n = 8 mice in each group