Table 9 Demographic information and MRI scan parameters related to Parkinson’s Disease research projects

TR

62.2 ms

–

36 ms

TR/TE

–

28/23 ms

–

Flip angle

15º

15°

20°

Bandwidth

–

–

–

FOV

–

230 × 230 × 180 mm³

–

Matrix size

–

256 × 256 × 180

512 × 512

Slice thickness

2 mm

–

–

Slice numbers

–

–

–

TEs

5 echoes

Range: 5.7–29.5 ms

–

5/12/19/26/33 ms

Total time

–

–

–

Sequence

3D multi-echo gradient-echo (mGRE)

SWI with velocity-compensated 3D fast-field echo

3D spoiled multi-echo GRE sequences (mGRE)

Participants

26 Patients with PD, 27 Patients with PSP, and 26 healthy subjects

31 Non-demented PD patients, 10 patients with PDD and 27 healthy subjects

26 Patients 26 patients with primary atypical Parkinsonisms,and 49 patients with PD

MRI scanner system

3T MRI System (Discovery MR 750w, GE Healthcare, USA)

3.0T MRI System (Philips Achieva)

3T MRI System (Philips Achieva)

TR

58.4 ms

32.80 ms

38 ms

TR/TE

–

–

–

Flip angle

15°

–

15°

Bandwidth

 ± 62.5 Hz

–

704 Hz/pixel

FOV

22 × 16.5 cm²

240 × 240 mm²

256 mm

Matrix size

320 × 416

320 × 320

256 × 256

Slice thickness

1.5 mm

–

1.5 mm

Slice numbers

1848

–

–

TEs

11 echoes

TE₁ = 4.5 ms

Time spacing = 5 ms

11.00 ms

4, 41.8 ms

Total time

7 min 1 s

528 s

9 min

Sequence

3D multi-echo spoiled gradient echo (mGRE)

multi-echo GRE sequence (mGRE)

GRE T2*

Participants

19 Patients with PD and 41 healthy subjects

3 Patients with schizophrenia, 4 patients with

dystonia, and 5 patients with Parkinson’s disease

30 Patients with PD and 15 healthy subjects

MRI scanner system

3T MRI System equipped with 8-channel phased-array coil

3T MRI System equipped with a 24-channel head coil

3T MRI System (Tim Trio Siemens Healthcare, Erlangen, Germany) With 32-channel coil