Table 10 Demographic information and MRI scan parameters related to other research projects

TR

60 ms

TR/TE

–

Flip angle

25°

Bandwidth

930 Hz/pixel

FOV

–

Matrix size

128 × 128 × 52

Slice thickness

–

Slice numbers

–

TEs

32 echoes, TE₁: 2.4/ΔTE = 1.42 ms

Total time

40 min

Sequence

3D mGRE sequence with a bipolar readout gradient (mGRE)

Participants

16 Healthy adult macaques

MRI scanner system

3T wholebody MRI system. (MAGNETOM Trio, Siemens Healthcare A.G., Erlangen, Germany)

TR

24.48 ms

24.55 ms

45.08 ms

45.03 ms

TR/TE

–

Flip angle

15 \(^\circ \)

15 \(^\circ \)

15 \(^\circ \)

15 \(^\circ \)

Bandwidth

244.14

244.14

244.14

244.14

FOV

220 × 176 mm²

220 × 176 mm²

220 × 176 mm²

220 × 176 mm²

Matrix size

320 × 320 × 86

320 × 320 × 74

320 × 320 × 86

320 × 320 × 74

Slice thickness

–

Slice numbers

–

TEs

5 echoes: 3.85/7.97/12.09/16.21 /20.33

5 echoes: 3.81/7.91/12.00/16.10/20.20

10 echoes: 3.85/7.97/12.09/16.21/20.33/24.45/28.57/32.69/36.81/40.93

10 echoes: 3.81/7.91/12.00/16.10/20.20/24.29/28.39/32.48/36.58/40.68

Total time

3 min and 35 s

2 min and 51 s

6 min and 36 s

5 min and 15 s

Sequence

3Dmultiple echo gradient echo (mGRE)

3Dmultiple echo gradient echo (mGRE)

Participants

10 healthy subjects

MRI scanner system

3T MRI System (Discovery MR750, General Electric Healthcare)

Prototype 7T MRI System (MR950, Signa 7.0T, General Electric Healthcare,Waukesha, WI)

TR

40 ms

–

–

TR/TE

–

49/40 ms

50/40 ms

Flip angle

15\(^\circ \)

15\(^\circ \)

16°

Bandwidth

217 Hz/px

25.6 kHz

FOV

224 × 224 × 140 mm³

230 × 207 × 136 mm³

230 × 230 × 132 mm³

Matrix size

–

–

128 × 128 × 66

Slice thickness

–

–

–

Slice numbers

–

–

–

TEs

6 echoes: TE₁: 6/ΔTE: 6 ms

–

–

Total time

7 min and 19 s

5 min and 50 s

7 min and 30 s

Sequence

3D multi-echo gradient echo (mGRE)

standard gradient recalled echo (GRE)

3D-radiofrequency spoiled GRE sequence

standard flow-compensated 3D fast spoiled-gradient-recalled (SPGR)

Participants

10 Healthy subjects

6 Healthy subjects

7 Healthy subjects

MRI scanner system

3T MRI System (Philips Achieva scanner)

1.5T MRI System (Siemens Medical Solution, Erlangen, Germany)

3T MRI System

(GE Healthcare,

Waukesha, WI, USA)

TR

24 ms

TR/TE

–

Flip angle

15\(^\circ \)

Bandwidth

490 Hz/pixel

FOV

–

Matrix size

–

Slice thickness

–

Slice numbers

–

TEs

5.00, 8.80, 12.60, 16.40 and 20.20 ms

Total time

3:54 min

Sequence

3D, multi gradient-echo pulse sequence (mGRE)

Participants

236 amyloid-b-positive subjects, 78 cognitively unimpaired, and 158 cognitively impaired patients

MRI scanner system

3T MRI System (Siemens Prisma 3 T scanner with a 64-channel receiver-coil array)

TR

53 ms

25 ms

25 ms

TR/TE

–

–

–

Flip angle

–

–

–

Bandwidth

–

–

–

FOV

–

–

–

Matrix size

–

–

–

Slice thickness

–

–

–

Slice numbers

–

–

–

TEs

40 ms

17.5 ms

17.5 ms

Total time

–

–

–

Sequence

Gradient echo imaging (GRE)

Gradient echo imaging (GRE)

Gradient echo imaging (GRE)

Participants

114 Healthy subjects

336 Healthy subjects

173 Healthy subjects

MRI scanner system

3T MRI System (Siemens Prisma 3.0T scanner)

3T MRI System (Philips Ingenia 3.0T scanner)

3T MRI System (GE HDX 1.5T scanner)