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Fig. 1 | BMC Neuroscience

Fig. 1

From: An in vivo accelerated developmental myelination model for testing promyelinating therapeutics

Fig. 1

Study design. A total of 68 rat pups were divided into 18 experimental groups of 5–7 pups/group, which received from one to nine daily injections of thyroxine (T4) or vehicle, starting from postnatal day 2 (PND2). Groups 1 and 2 received T4 or vehicle, respectively, on PND2 and were sacrificed on PND3, groups 3 and 4 received T4 or vehicle, respectively, on PND2 and PND3 and were sacrificed on PND4, etc. Animals were sampled daily from PND3 to PND11, and brain hemispheres were collected for IHC and RR-ELISA experiments. Diffusion tensor MRI (DTI) was performed on PND10 for vehicle and T4 rat pups (group 17 and group 18)

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