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Fig. 5 | BMC Neuroscience

Fig. 5

From: Fmr1 exon 14 skipping in late embryonic development of the rat forebrain

Fig. 5

Graphic scheme correlating the summary of the results to known neurodevelopmental aspects of FMRP. The column graphic style of the illustration presents the relative amount of total Fmr1 transcripts in the forebrain as columns, in a limited period of the development: the last two embryonic weeks (2 and 3) and the first three postnatal weeks (1–2 and 3). According to the data presented here, total Fmr1 mRNA reaches its highest values on the second embryonic and first postnatal weeks. Low levels of Fmr1 mRNA are observed in the third embryonic week as well as after the second postnatal week. In each pictured graph column of total Fmr1 mRNA, the most abundant exon 13 junction is represented on the top, while on the bottom part is the least frequently observed one in a fading color tone. A drawing of the predominant neuronal differentiation process that takes place in each of the illustrated developmental week highlights the first three graph columns. Each process is associated with a developmental period, representing neurogenesis that predominates in embryonic week 2, neuron migration in embryonic week 3; and synaptogenesis starting in postnatal weeks 1 and 2

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