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Fig. 8 | BMC Neuroscience

Fig. 8

From: Cellular distribution of C-C motif chemokine ligand 2 like immunoreactivities in frontal cortex and corpus callosum of normal and lipopolysaccharide treated animal

Fig. 8

Comparison of co-localization of the CCL2-ir and the other cellular markers in cortex and CC. A The number of CCL2-ir and GFAP double labeled structures in saline CC+Epend is significantly higher than that in saline cortex (p < 0.001), revealed by ANOVA and post-test. And systemic LPS significantly enhanced the number of these co-localization in the CC+Epend comparing to its normal counterpart (p < 0.01). These co-localization number is also significantly increased in the cortex of LPS treated mice versus the saline cortex (p < 0.01). Meanwhile, in the LPS injected animals, the co-labeled structures in the CC+Epend is significantly higher than in the cortex (p < 0.001). B The number of CCL2-ir and Iba-1 co-labeled structures is significantly upgraded in both the cortex and CC+Epend of LPS treated mice, comparing to these number in both the cortex and CC +Epend of normal and saline ones (p < 0.05 for both). C The numbers of CCL2-ir and NeuN co-localization are significantly higher in naïve and saline cortex than that in naïve and saline CC (p < 0.001 for Ctx vs CC in naïve mice; p < 0.01 for Ctx vs CC in saline ones). Systemic LPS significantly increased these co-localizations in the cortex (p < 0.05) but not in the CC. Likewise, in the LPS treated mice, the number of CCL2-ir positive neurons in the cortex is significantly higher than that in the CC (p < 0.001)

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