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Fig. 2 | BMC Neuroscience

Fig. 2

From: Paeonol regulates NLRP3 inflammasomes and pyroptosis to alleviate spinal cord injury of rat

Fig. 2

Paeonol represses the pyroptosis and formation of NLRP3 inflammasome in SCI rat model. A The mRNA expression of caspase1 and NLRP3 at 1, 3, and 7 days after SCI. ***P < 0.01 vs. the sham group. (B) The western blot assay images (20 μg/lane) for the levels of ASC, NLRP3, active caspase 1, and N-GSDMD in spinal cord tissues. (C) The protein level of ASC in spinal cord tissues was measured by western blot assay. (D) The protein level of NLRP3 in spinal cord tissues was measured by western blot assay. (E) The protein level of active caspase 1 in spinal cord tissues was measured by western blot assay. (F) The protein level of N-GSDMD in spinal cord tissues was measured by western blot assay. (G) The number of TUNEL-positive neuron was measured by TUNEL staining assay. ***P < 0.001 vs. the sham group. ###P < 0.001 vs. the SCI + CMC-Na group

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