Rifaximin modulates TRH and TRH-like peptide expression throughout the brain and peripheral tissues of male rats

Pekary, Albert Eugene; Sattin, Albert

doi:10.1186/s12868-022-00694-z

BMC Neuroscience

Table 3 Effect of acute (AC), chronic (CHR) and withdrawal (WD) treatments with rifaximin on TRH and TRH-like peptide levels in peripheral tissues (pg)

From: Rifaximin modulates TRH and TRH-like peptide expression throughout the brain and peripheral tissues of male rats

Prostate	Glu-TRH	Peak 2	TRH	Val-TRH	Tyr-TRH	Leu-TRH	Phe-TRH	Trp-TRH
CON	1898 ± 645	48,829 ± 15,625	2068 ± 765	12,830 ± 3464	71,618 ± 22,202	9626 ± 3562	9435 ± 2925	4285 ± 1328
AC	1993 ± 678	39,195 ± 12,542	800 ± 296	8922 ± 2409	3748 ± 1162*	13,415 ± 4964	47,016 ± 14,575*	2981 ± 924
CHR	1827 ± 621	33,166 ± 10,613	9192 ± 3401	41,357 ± 11,166	8858 ± 2746*	4079 ± 1509	8103 ± 2512	3971 ± 1231
WD	3215 ± 1093	54,959 ± 17,587	25,935 ± 9596*	64,372 ± 17,380*	1640 ± 508*	4200 ± 1554	10,188 ± 3158	4346 ± 1347
Liver
CON	277 ± 66	216 ± 41	584 ± 228	361 ± 105	58 ± 17	765 ± 245	452 ± 145	327 ± 75
AC	426 ± 102	313 ± 59	954 ± 372	394 ± 114	36 ± 11	1390 ± 445	930 ± 298	708 ± 163
CHR	586 ± 141	385 ± 73	1919 ± 748	2050 ± 595*	230 ± 69	537 ± 172	923 ± 295	360 ± 83
WD	626 ± 150	224 ± 43	1427 ± 557	738 ± 214	2073 ± 622*	571 ± 183	1167 ± 373	451 ± 104
Testis
CON	43 ± 10	260 ± 99	714 ± 150	448 ± 54	2228 ± 646	656 ± 190	610 ± 140	174 ± 52
AC	93 ± 21	68 ± 26	370 ± 78	515 ± 62	2343 ± 679	807 ± 234	623 ± 143	448 ± 134
CHR	275 ± 63*	218 ± 83	693 ± 146	716 ± 86	3005 ± 871	957 ± 278	1190 ± 274	521 ± 156
WD	83 ± 19	160 ± 61	392 ± 82	460 ± 55	961 ± 279	516 ± 150	577 ± 133	442 ± 133
Heart
CON	181 ± 54	134 ± 24	427 ± 51	408 ± 126	104 ± 31	533 ± 139	575 ± 196	271 ± 98
AC	170 ± 51	86 ± 15	242 ± 29	114 ± 35	159 ± 48	233 ± 61	247 ± 84	195 ± 70
CHR	123 ± 37	102 ± 18	271 ± 33	344 ± 107	73 ± 22	304 ± 79	776 ± 264	415 ± 149
WD	381 ± 114	203 ± 37	312 ± 37	137 ± 42	283 ± 85	227 ± 59	422 ± 143	307 ± 111
Pancreas
CON	234 ± 82	279 ± 95	139 ± 58	206 ± 47	214 ± 45	870 ± 200	464 ± 97	531 ± 117
AC	191 ± 67	243 ± 83	115 ± 48	175 ± 40	165 ± 35	503 ± 116	419 ± 88	319 ± 70
CHR	101 ± 35	313 ± 106	173 ± 73	168 ± 39	114 ± 24	508 ± 117	1085 ± 228*	620 ± 136
WD	344 ± 120	238 ± 81	64 ± 27	75 ± 17	80 ± 17*	241 ± 55*	398 ± 84	523 ± 115
Adrenals
CON	588 ± 188	1905 ± 286	1577 ± 315	1169 ± 339	2109 ± 970	1432 ± 473	1877 ± 507	1101 ± 374
AC	484 ± 155	1194 ± 179	856 ± 171	934 ± 271	1641 ± 755	535 ± 177	1288 ± 348	1145 ± 389
CHR	403 ± 129	835 ± 125*	871 ± 174	564 ± 164	1646 ± 757	616 ± 203	701 ± 189	216 ± 73
WD	74 ± 24	124 ± 19**	692 ± 138*	523 ± 152	631 ± 290	198 ± 65*	448 ± 121	124 ± 42

All results are mean ± SD
^*p < 0.05; **p < 0.01 by one way ANOVA using post hoc Scheffe contrasts versus the control group

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