Fig. 1

Representative profiles of TRH and TRH-like peptide responses in male rats to RF treatment. The response patterns in A and D are consistent with rapid and sustained increase in peptide release (reduced peptide level). The profile in B suggests rapid and sustained decrease in peptide release during and after RF exposure. C could be explained by RF stimulation of sustained peptide release which is compensated by increased peptide synthesis. Withdrawal of RF reduced peptide release but the compensatory increase in peptide synthesis results in a rebound increase in peptide content. The persistence of changes in TRH and TRH-like peptide levels in the WD group after RF has completely cleared from the GI tract is consistent with lingering effects of an altered microbiome