Skip to main content
Fig. 4 | BMC Neuroscience

Fig. 4

From: Maternal diabetes-mediated RORA suppression contributes to gastrointestinal symptoms in autism-like mouse offspring

Fig. 4

RORA agonist and SOD mimetic reverse maternal diabetes-mediated RORA suppression and oxidative stress in IEC. Dams were divided into the following treatment groups: control (CTL/VEH), diabetes (STZ/VEH), diabetes plus SOD mimetic MnTBAP (STZ/MnTBAP), or diabetes plus RORA agonist SR1078 (STZ/SR1078) during pregnancy, and the IEC cells were isolated from male offspring for biomedical analysis. a mRNA levels by qPCR, n = 4. b Quantitation of protein levels, n = 5. c Representative pictures of western blotting for b, and full-length blots are presented in Additional file 1: Fig. S1b. d ROS formation, n = 5. e 8-OHdG formation, n = 5. f SOD2 activity, n = 5. The one-way ANOVA analysis was performed to determine statistical significance of different groups. *P<0.05, vs. CTL/VEH group; ¶P<0.05, vs. STZ/VEH group. Data were expressed as mean ± SD

Back to article page