Parameter | EAE score |
---|
Groups | Day 13 | Day 14 | Day 15 | Day 16 | Day 17 |
---|
CNSED | 0(0–0) | 0(0–0) | 0(0–0) | 0(0–0) | 0(0–0) |
CNEX | 0(0–0) | 0(0–0) | 0(0–0) | 0(0–0) | 0(0–0) |
EAESED | 1(1–1) | 2(2–2) | 2(2–3) | 2(2–3) | 4(2–4)* |
EAEEX | 1(1–1) | 2(2–2) | 2(2–2) | 3(2–3) | 4(2–4)$ |
MTSED | 1(1–1) | 1(1–2) | 2(2–2) | 2(2–3) | 1.5(1–2)*# |
MTEX | 1(1–1) | 1(1–1) | 2(1–2) | 2(2–5) | 2.5(2–5) $& |
- Non-parametric score data are shown as median with its minimum and maximum range (n = 6). Comparisons between groups at each time interval was analyzed using Kruskal–Wallis Test, followed by Dunn's post hoc test, p < 0.05. As compared with (*) CNSED, ($) CNEX, (#) EAESED and (&) MTSED groups. EAE experimental autoimmune encephalomyelitis, CNSED sedentary control, CNEX exercised control; EAESED: sedentary untreated EAE, EAEEX exercised untreated EAE, MTSED sedentary mitoxantrone, MTEX exercised mitoxantrone treated rats