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Table 3 Effect of mitoxantrone on EAE score in sedentary and exercised EAE rats (day 13–day 17)

From: Does physical exercise improve or deteriorate treatment of multiple sclerosis with mitoxantrone? Experimental autoimmune encephalomyelitis study in rats

Parameter

EAE score

Groups

Day 13

Day 14

Day 15

Day 16

Day 17

CNSED

0(0–0)

0(0–0)

0(0–0)

0(0–0)

0(0–0)

CNEX

0(0–0)

0(0–0)

0(0–0)

0(0–0)

0(0–0)

EAESED

1(1–1)

2(2–2)

2(2–3)

2(2–3)

4(2–4)*

EAEEX

1(1–1)

2(2–2)

2(2–2)

3(2–3)

4(2–4)$

MTSED

1(1–1)

1(1–2)

2(2–2)

2(2–3)

1.5(1–2)*#

MTEX

1(1–1)

1(1–1)

2(1–2)

2(2–5)

2.5(2–5) $&

  1. Non-parametric score data are shown as median with its minimum and maximum range (n = 6). Comparisons between groups at each time interval was analyzed using Kruskal–Wallis Test, followed by Dunn's post hoc test, p < 0.05. As compared with (*) CNSED, ($) CNEX, (#) EAESED and (&) MTSED groups. EAE experimental autoimmune encephalomyelitis, CNSED sedentary control, CNEX exercised control; EAESED: sedentary untreated EAE, EAEEX exercised untreated EAE, MTSED sedentary mitoxantrone, MTEX exercised mitoxantrone treated rats