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Fig. 7 | BMC Neuroscience

Fig. 7

From: Does physical exercise improve or deteriorate treatment of multiple sclerosis with mitoxantrone? Experimental autoimmune encephalomyelitis study in rats

Fig. 7

Effect of mitoxantrone on activated caspase-3 in the brain stem. Compared to the negative immunostaining of caspase 3 in A normal control group, sections of EAE untreated rat show positive staining in the astrocytes and neurons surrounding the plaques (arrows) of B sedentary/C exercised groups. Sections of mitoxantrone treated group show few positively stained astrocytes and neurons in the plaques of D sedentary/E exercised rats. Panel F shows the influence of exercise on the amount of caspase-3 positive cells in brain stem. Values are presented as mean ± S.D. (n = 6/group). Comparison inside the same group was done using one-way ANOVA followed by Tukey's Multiple Comparison Test. Comparison between sedentary and exercised groups was done using two-way ANOVA followed by Bonferroni Correction Test (p < 0.05). As compared with CNSED (*), CNEX ($), EAESED (#), EAEEX (%) and exercised vs sedentary rats (ψ). EAE experimental autoimmune encephalomyelitis; groups of CNSED sedentary control, CNEX exercised control, EAESED sedentary untreated EAE, EAEEX exercised untreated EAE, MTSED sedentary mitoxantrone, MTEX exercised mitoxantrone

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BMC Neuroscience

ISSN: 1471-2202

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