Fig. 1From: Does physical exercise improve or deteriorate treatment of multiple sclerosis with mitoxantrone? Experimental autoimmune encephalomyelitis study in ratsExperimental design timeline. Rats were familiarized to rotarod running before EAE induction (days -14 to -1). After EAE induction (on day 0), control and EAE rats were subjected to daily physical exercise for 17 days. Upon appearance of EAE symptoms (score 1, on day 13) rats were subjected to treatment with mitoxantrone (MT). Finally, all rats were sacrificed on day 18. EAE experimental autoimmune encephalomyelitis, CNSED sedentary control, CNEX exercised control; EAESED = sedentary untreated EAE; EAEEX = exercised untreated EAE ratsBack to article page