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Fig. 5 | BMC Neuroscience

Fig. 5

From: The effect of a novel anticonvulsant chemical Q808 on gut microbiota and hippocampus neurotransmitters in pentylenetetrazole-induced seizures in rats

Fig. 5

Normalized intensity of neurotransmitters in the hippocampi of the rats in three groups (n = 6). In the seizure model group, the content of GABA was drastically decreased compared with that in control group (p = 0.011). After Q808 treatment, the content of acetylcholine increased (p = 0.002 compared with the PTZ group), whereas the levels of 3-methoxytyramine, glutamine, and 5-HIAA decreased (p = 0.003, p = 0.001, and p = 0.0004, separately, compared with the control group). No significant differences were observed in the levels of normetanephrine, norepinephrine, glutamate, dopamine, histamine, and serotonin among the three groups. Data were means ± SEM and analyzed using the Kruskal–Wallis and Dunn’s non-parametric test. *p < 0.05, **p < 0.01, ***p < 0.001

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