Increased expression of pathological markers in Parkinson’s disease dementia post-mortem brains compared to dementia with Lewy bodies

Table 5 Statistic results of LRRK2-related proteins tested in three regions of Control (Ctrl), PDD, and DLB post-mortem samples

Protein	Region	PDD/Ctrl	DLB/Ctrl	PDD/DLB
LRRK2	SN	NS	NS	NS
	CP	NS	NS	NS
	TC	NS	NS	NS
p-LRRK2^S935	TC	↑* (0.023)	NS	NS
Rab10	SN	NS	NS	NS
	CP	NS	NS	NS
	TC	↑*** (0.0006)	↑** (0.002)	NS
p-Rab10^T73/Rab10	TC	NS	↓** (0.002)	NS
VPS35	SN	↑ (0.067)	NS	NS
	CP	NS	NS	NS
	TC	NS	NS	↑* (0.037)
14-3-3	SN	NS	NS	NS
	CP	NS	NS	NS
	TC	NS	NS	NS

Statistical results from western blot results for LRRK2-substrate proteins tested in this study. Western blot images were quantified using ImageJ, and the data were normalized to β-actin. The upwards arrow indicates an increase and the downwards arrow indicates a decrease. p < 0.1 was included in the bracket to show the trends of the protein levels. Kruskal–Wallis test was used to measure the differences between Control, PDD, and DLB samples
NS no significance
*p < 0.05, **p < 0.01, ***p < 0.001

ISSN: 1471-2202