Fig. 5
From: Metformin attenuates sepsis-induced neuronal injury and cognitive impairment
Metformin alleviates CLP-induced synaptic dysfunction. A, B CA3-CA1 fEPSP mean slope recorded from the CA1 dendritic region in hippocampal slices, n  = 3. Hippocampal tissues were homogenized, and synaptic protein levels were detected by immunoblotting (C). Postsynaptic proteins NR2B (D), PSD95 (E) and pre-synaptic proteins SYN (F), SYT (G) were evaluated. n  =  3. p value significance is calculated from a one-way ANOVA or two-way ANOVA tests, all data represent mean  ±  SEM. *p  < 0.05, **p  < 0.01 vs CLP group