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Fig. 6 | BMC Neuroscience

Fig. 6

From: Metformin attenuates LPS-induced neuronal injury and cognitive impairments by blocking NF-κB pathway

Fig. 6

Metformin pretreatment attenuates the release of inflammatory factors via preventing the activation of the NF-κB pathway. AC Enzyme-linked immunosorbent assay (ELISA) Kits was used to detect inflammatory factors including IL-1β (A), IL-6 (B), and TNF-α (C). We separate cytosolic and nuclear proteins: NF-κB in the cytoplasm (D, E) and nucleus (F, G) was measured. n = 3. p value significance is calculated from a one-way ANOVA test, all data represent mean ± SEM. *p < 0.05, **p < 0.01 vs LPS group

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