Fig. 4

The SH-SY5Y cell line was transfected with TRDN siRNA(siTRDN) for 24 h. Negative control (NC) was transfected with 100 nM NC siRNA, and the others were transfected with 10- and 100-nM TRDN siRNA. The tyrosine hydroxylase (TH) level was consistently decreased in the 10- and 100-nM siTRDN treatment groups. The Bax level did not show significant changes, but the Bcl-2 level tended to decrease. The Bax/Bcl-2 ratio increased according to the decrease in TRDN level (*P < 0.05, **P < 0.005)