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Table 3 Results of the over-representation analysis using the Reactome database

From: A systematic review of common genetic variation and biological pathways in autism spectrum disorder

Term # Genes p-value
Neuronal system 28 ABAT, ACE, CDH8, EGF, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, GRIK2, GRIN2A, GRIN2B, HOMER1, HTR3A, KCNJ10, MAOA, NLGN4X, NLGN4Y, NRXN1, NRXN2, PRKCB1, DLG4, SHANK2, SHANK3, SLC6A4, SNAP25, STX1A 1.11 × 10−16
Neurexins and neuroligins 11 GRIN2A, GRIN2B, HOMER1, NLGN4X, NLGN4Y, NRXN1, NRXN2, DLG4, SHANK2, SHANK3, STX1A 6.25 × 10−14
Transmission across Chemical Synapses 20 ABAT, ACE, EGF, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, GRIK2, GRIN2A, GRIN2B, HTR3A, KCNJ10, MAOA, PRKCB1, DLG4, SLC6A4, SNAP25, STX1A 7.85 × 10−12
Protein–protein interaction at synapses 11 GRIN2A, GRIN2B HOMER1, NLGN4X, NLGN4Y, NRXN1, NRXN2, DLG4, SHANK2, SHANK3, STX1A 1.41 × 10−11
Transcriptional Regulation by MECP2 5 BDNF, GRIN2A, GRIN2B, MECP2, MET 4.91 × 10−10
MECP2 regulates neuronal receptors and channels 4 GRIN2A, GRIN2B, MECP2, MET 1.56 × 10−9
Neurotransmitter receptors and postsynaptic signal transmission 14 EGF, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, GRIK2, GRIN2A, GRIN2B, HTR3A, KCNJ10, PRKCB1, DLG4 1.72 × 10−9
GABA receptor activation 8 EGF, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, KCNJ10 2.99 × 10−8
  1. The most significant pathways, according to p-value, are included