Table 3 Results of the over-representation analysis using the Reactome database

Neuronal system

28

ABAT, ACE, CDH8, EGF, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, GRIK2, GRIN2A, GRIN2B, HOMER1, HTR3A, KCNJ10, MAOA, NLGN4X, NLGN4Y, NRXN1, NRXN2, PRKCB1, DLG4, SHANK2, SHANK3, SLC6A4, SNAP25, STX1A

1.11 × 10⁻¹⁶

Neurexins and neuroligins

11

GRIN2A, GRIN2B, HOMER1, NLGN4X, NLGN4Y, NRXN1, NRXN2, DLG4, SHANK2, SHANK3, STX1A

6.25 × 10⁻¹⁴

Transmission across Chemical Synapses

20

ABAT, ACE, EGF, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, GRIK2, GRIN2A, GRIN2B, HTR3A, KCNJ10, MAOA, PRKCB1, DLG4, SLC6A4, SNAP25, STX1A

7.85 × 10⁻¹²

Protein–protein interaction at synapses

11

GRIN2A, GRIN2B HOMER1, NLGN4X, NLGN4Y, NRXN1, NRXN2, DLG4, SHANK2, SHANK3, STX1A

1.41 × 10⁻¹¹

Transcriptional Regulation by MECP2

5

BDNF, GRIN2A, GRIN2B, MECP2, MET

4.91 × 10⁻¹⁰

MECP2 regulates neuronal receptors and channels

4

GRIN2A, GRIN2B, MECP2, MET

1.56 × 10⁻⁹

Neurotransmitter receptors and postsynaptic signal transmission

14

EGF, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, GRIK2, GRIN2A, GRIN2B, HTR3A, KCNJ10, PRKCB1, DLG4

1.72 × 10⁻⁹

GABA receptor activation

8

EGF, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, KCNJ10

2.99 × 10⁻⁸