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Table 2 Results of the over-representation analysis using the GO Biological Process (BP) database

From: A systematic review of common genetic variation and biological pathways in autism spectrum disorder

Term

#

Genes

p-value

Bonferroni

Social behavior

13

SHANK2, SHANK3, AVPR1A, CNTNAP2, DRD3, MECP2, NRXN1, NRXN2, NLGN4X, NLGN4Y, OXTR, PTCHD1, SLC6A4

1.5 × 10−15

2 × 10−12

Vocalization behavior

7

SHANK2, SHANK3, CNTNAP2, DLG4, NRXN1, NRXN2, NLGN4X, NLGN4Y

5.5 × 10−10

7.5 × 10−7

Adult behavior

8

SHANK2, SHANK3, CNTNAP2, GABRG2, GRM7, NRXN1, NRXN2, NLGN4X

8.2 × 10−10

1.1 × 10−6

Synapse assembly

10

SHANK2, SHANK3, BDNF, DRD1, DRD2 MECP2, NRXN1, NRXN2, NLGN4Y, NRCAM

9.3 × 10–10

1.3 × 10−6

Memory

10

HTR2A, CX3CR1, SHANK2, SHANK3, CHRNA7, DRD1, GRIN2A, OXTR, PTGS2, SLC6A4

1.2 × 10−8

1.7 × 10−5

Positive regulation of synaptic transmission, glutamatergic

7

SHANK2, SHANK3, DRD1, NRXN1, OXTR, PTGS2, RELN

4.8 × 10−9

6.6 × 10−6

Learning

9

SHANK2, SHANK3, CNTNAP2, DRD1, DRD3, NRXN1, NLGN4X, NLGN4Y, PTGS2

1.2 × 10−8

1.7 × 10−5

Vocal learning

5

SHANK3, CNTNAP2, FOXP2, NRXN1, NRXN2

1.2 × 10−7

1.6 × 10−4

Long-term synaptic potentiation

7

SHANK2, SHANK3, DRD1, GRIN2A, MECP2, RELN, SNAP25

4.3 × 10−7

5.9 × 10−4

Chemical synaptic transmission

12

HTR2A, CACNA1G, GABRA5, GRIN2A, GRIN2B, GRIK2, GRM7, HOMER1, NRXN1, NRXN2, SLC6A4, SNAP25

2.6 × 10−6

3.6 × 10−3

  1. The ten most significant terms using Bonferroni correction are included
  2. GO gene ontology