From: A systematic review of common genetic variation and biological pathways in autism spectrum disorder
Term | # | Genes | p-value | Bonferroni |
---|---|---|---|---|
Social behavior | 13 | SHANK2, SHANK3, AVPR1A, CNTNAP2, DRD3, MECP2, NRXN1, NRXN2, NLGN4X, NLGN4Y, OXTR, PTCHD1, SLC6A4 | 1.5 × 10−15 | 2 × 10−12 |
Vocalization behavior | 7 | SHANK2, SHANK3, CNTNAP2, DLG4, NRXN1, NRXN2, NLGN4X, NLGN4Y | 5.5 × 10−10 | 7.5 × 10−7 |
Adult behavior | 8 | SHANK2, SHANK3, CNTNAP2, GABRG2, GRM7, NRXN1, NRXN2, NLGN4X | 8.2 × 10−10 | 1.1 × 10−6 |
Synapse assembly | 10 | SHANK2, SHANK3, BDNF, DRD1, DRD2 MECP2, NRXN1, NRXN2, NLGN4Y, NRCAM | 9.3 × 10–10 | 1.3 × 10−6 |
Memory | 10 | HTR2A, CX3CR1, SHANK2, SHANK3, CHRNA7, DRD1, GRIN2A, OXTR, PTGS2, SLC6A4 | 1.2 × 10−8 | 1.7 × 10−5 |
Positive regulation of synaptic transmission, glutamatergic | 7 | SHANK2, SHANK3, DRD1, NRXN1, OXTR, PTGS2, RELN | 4.8 × 10−9 | 6.6 × 10−6 |
Learning | 9 | SHANK2, SHANK3, CNTNAP2, DRD1, DRD3, NRXN1, NLGN4X, NLGN4Y, PTGS2 | 1.2 × 10−8 | 1.7 × 10−5 |
Vocal learning | 5 | SHANK3, CNTNAP2, FOXP2, NRXN1, NRXN2 | 1.2 × 10−7 | 1.6 × 10−4 |
Long-term synaptic potentiation | 7 | SHANK2, SHANK3, DRD1, GRIN2A, MECP2, RELN, SNAP25 | 4.3 × 10−7 | 5.9 × 10−4 |
Chemical synaptic transmission | 12 | HTR2A, CACNA1G, GABRA5, GRIN2A, GRIN2B, GRIK2, GRM7, HOMER1, NRXN1, NRXN2, SLC6A4, SNAP25 | 2.6 × 10−6 | 3.6 × 10−3 |