Skip to main content

Table 2 Results of the over-representation analysis using the GO Biological Process (BP) database

From: A systematic review of common genetic variation and biological pathways in autism spectrum disorder

Term # Genes p-value Bonferroni
Social behavior 13 SHANK2, SHANK3, AVPR1A, CNTNAP2, DRD3, MECP2, NRXN1, NRXN2, NLGN4X, NLGN4Y, OXTR, PTCHD1, SLC6A4 1.5 × 10−15 2 × 10−12
Vocalization behavior 7 SHANK2, SHANK3, CNTNAP2, DLG4, NRXN1, NRXN2, NLGN4X, NLGN4Y 5.5 × 10−10 7.5 × 10−7
Adult behavior 8 SHANK2, SHANK3, CNTNAP2, GABRG2, GRM7, NRXN1, NRXN2, NLGN4X 8.2 × 10−10 1.1 × 10−6
Synapse assembly 10 SHANK2, SHANK3, BDNF, DRD1, DRD2 MECP2, NRXN1, NRXN2, NLGN4Y, NRCAM 9.3 × 10–10 1.3 × 10−6
Memory 10 HTR2A, CX3CR1, SHANK2, SHANK3, CHRNA7, DRD1, GRIN2A, OXTR, PTGS2, SLC6A4 1.2 × 10−8 1.7 × 10−5
Positive regulation of synaptic transmission, glutamatergic 7 SHANK2, SHANK3, DRD1, NRXN1, OXTR, PTGS2, RELN 4.8 × 10−9 6.6 × 10−6
Learning 9 SHANK2, SHANK3, CNTNAP2, DRD1, DRD3, NRXN1, NLGN4X, NLGN4Y, PTGS2 1.2 × 10−8 1.7 × 10−5
Vocal learning 5 SHANK3, CNTNAP2, FOXP2, NRXN1, NRXN2 1.2 × 10−7 1.6 × 10−4
Long-term synaptic potentiation 7 SHANK2, SHANK3, DRD1, GRIN2A, MECP2, RELN, SNAP25 4.3 × 10−7 5.9 × 10−4
Chemical synaptic transmission 12 HTR2A, CACNA1G, GABRA5, GRIN2A, GRIN2B, GRIK2, GRM7, HOMER1, NRXN1, NRXN2, SLC6A4, SNAP25 2.6 × 10−6 3.6 × 10−3
  1. The ten most significant terms using Bonferroni correction are included
  2. GO gene ontology