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Table 1 Results of the over-representation analysis using the KEGG Pathway database

From: A systematic review of common genetic variation and biological pathways in autism spectrum disorder

Term # Genes p-value Bonferroni
Serotonergic synapse 13 HTR2A, HTR3A, CACNA1C, DDC, GABRB1, GABRB3, MAOA, MAOB, PLA2G4C, PTGS2, PRKCB, SLC6A4, TPH2 3.4 × 10−8 3.2 × 10−6
Neuroactive ligand-receptor interaction 19 HTR2A, ADRB2, AVPR1A, DRD1, DRD2, DRD3, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, GRIN2A, GRIN2B, GRIK2, GRIK5, GRM7, OXTR, VIPR2 3.6 × 10−8 3.2 × 10−6
Calcium signaling pathway 14 HTR2A, ATP2B2, ADRB2, AVPR1A, CACNA1C, CACNA1G, CHRNA7, DRD1, GRIN2A, NOS2, OXTR, PRKCB, SLC25A6 9.9 × 10−7 3.0 × 10−5
Dopaminergic synapse 12 CACNA1C, DDC, DRD1, DRD2, DRD3, GRIN2A, GRIN2B, MAOA, MAOB, PRKCB, PPP2R5D, SLC18A1 1.4 × 10−6 3.5 × 10−5
GABAergic synapse 9 ABAT, CACNA1C, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, PRKCB 2.1 × 10−5 4.8 × 10−4
Glutamatergic synapse 10 SHANK2, SHANK3, CACNA1C, GRIN2A, GRIN2B, GRIK5, GRM7, HOMER1, PLA2G4C, PRKCB 2.7 × 10−5 5.3 × 10−4
Retrograde endocannabinoid signaling 9 CACNA1C, GABRA4, GABRA5, GABRB1, GABRB3, GABRG2, GABRG3, PTGS2, PRKCB 7.5 × 10−5 1.3 × 10−3
Tryptophan metabolism 7 ASMT, AADAT, DDC, MAOA, MAOB, TDO2 2.1 × 10−4 3.5 × 10−3
  1. Significant terms using Bonferroni correction are included. Other disease processes are not presented in this table
  2. KEGG Kyoto encyclopedia of genes and genomes, GABA γ-aminobutyric acid