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Fig. 2 | BMC Neuroscience

Fig. 2

From: NRXN1α+/- is associated with increased excitability in ASD iPSC-derived neurons

Fig. 2

NRXN1α+/- deletion significantly impairs voltage-gated Na+ currents. Representative traces of voltage clamp recording from A control (n = 45 cells from 29 coverslips) and from B NRXN1α+/- (n = 27 cells on 17 coverslips) iPSC-derived neurons, showing fast inward Na+ currents followed by slow outward K+ currents, in response to different voltage step applied. C Average Na+ and K+ currents from both controls (black) and NRXN1α+/- (red) neurons, showing significant increases of the inward Na+ in a voltage-dependent manner in the NRXN1α+/- neurons. D The data from panel C were normalized to maximal Na+ (G/Gmax) E, and also normalized to Na+ conductance (I/Imax) and plotted against voltage steps, with significant increase at − 30 mV (** p < 0.002) and no significant change at − 20 mV (p = 0.23). Data were presented as mean ± SEM. Statistical significance (** p < 0.01) were evaluated using Man Whitney U test or repeated measure ANOVA

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