Table 1 The cellular uptake of Aβ1-42 in GFP-HEK293T cells and OATP1B1-GFP-HEK293T cells following incubation with 0.4, 1, 2.5 μM Aβ1-42 for 24, 48, 72 h, respectively (n = 3)
From: Uptake of Aβ by OATPs might be a new pathophysiological mechanism of Alzheimer disease
Aβ1-42 0 μM | Aβ1-42 0.4 μM | Aβ1-421 μM | Aβ1-42 2.5 μM | |||||
|---|---|---|---|---|---|---|---|---|
NC | OATP1B1 | NC | OATP1B1 | NC | OATP1B1 | NC | OATP1B1 | |
24 h | 0.52 ± 0.05 | 0.47 ± 0.12 | 9.16 ± 0.93 | 10.88 ± 0.31* | 16.28 ± 2.42 | 24.50 ± 4.48* | 36.01 ± 4.25 | 42.00 ± 4.27 |
48 h | 0.62 ± 0.11 | 0.67 ± 0.15 | 12.18 ± 0.25 | 19.87 ± 1.70** | 20.07 ± 0.98 | 49.42 ± 3.02** | 37.04 ± 1.77 | 65.38 ± 4.52** |
72 h | 0.52 ± 0.07 | 0.63 ± 0.10 | 16.92 ± 0.20 | 29.53 ± 2.58** | 24.61 ± 4.57 | 56.60 ± 8.03** | 44.39 ± 5.76 | 84.13 ± 3.03** |