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Fig. 5 | BMC Neuroscience

Fig. 5

From: Uptake of Aβ by OATPs might be a new pathophysiological mechanism of Alzheimer disease

Fig. 5

Flow cytometry showing the cellular uptake of Aβ 1–42 in GFP-HEK293T cells and OATP1B1-GFP-HEK293T cells following incubation with 0.4, 1, 2.5 μM Aβ (1–42) for 24, 48, 72 h, respectively. Uptake of Aβ 1–42 increased both in GFP-HEK293T cells and OATP1B1-GFP-HEK293T, and compared to GFP-HEK293T cells, the uptake of Aβ1-42 in OATP1B1-GFP-HEK293Tcells increased significantly with the increase in duration of incubation. Especially, when the incubation time was 72 h, the uptake of Aβ1-42 in OATP1B1-HEK293T was almost twice as much as that in the HEK293T group. *indicates P < 0.05; **indicates P < 0.01. NC: GFP-HEK293T cells; OATP1B1:OATP1B1-GFP-HEK293T cells. n = 3

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