Fig. 4

Effects of 2-ethil-6-methil-3-hydroxypiridin succinate on Neurons and glial cells of rat brain tissue after the traumatic brain injury. (A) Neurons and glial cells of control rats and rat under the action of 2-ethil-6-methil-3-hydroxypiridin succinate. Scale bar is 50 μm, magnification × 400. (B) Quantification of pericellular edema around the neurons and glia cells. (1 on the first day of post-traumatic period, there was a strongly pronounced pericellular edema around neurons and glia cells. The intercellular substance had an almost frothy appearance; 2 on the 3rd day of post-traumatic period there was a strongly expressed pericellular edema around neurons and glia cells. Moderate amount of vacuoles was in the intercellular substance; 3 on the 7th day of the post-traumatic period edema around the neurons and glia cells was moderate. Small number of vacuoles was in the intercellular substance; 4 on the 12th day of the post-traumatic period there was was a moderate pericellular edema around neurons and glia cells. Single vacuoles were in the intercellular substance; 5 on the 1st day of the post-traumatic period there was a severe pericellular edema around neurons and glia cells. Moderate amount of vacuoles was in the intercellular substance; 6 on the 3st day of the post-traumatic period there was a moderate pericellular edema around neurons and glia cells. Moderate amount of vacuoles was in the intercellular substance; 7 on the 7th day of the post-traumatic period there was a weakly expressed pericellular edema around neurons and glia cells. Single vacuoles were in the intercellular substance; 8—on the 12 day of the post-traumatic period the pericellular edema around the neurons and glia cells was absent. The intercellular substance was not vacuolated). Examples of pericellular edema around the neurons and glia cells are indicated by arrows