Fig. 1

Schematic diagram of PLGA scaffold with aligned inner surface and random outer surface orientated fibers were fabricated by the electrospinning method. The inner surfaces of PLGA nerve conduit coated with laminin containing BDNF and AuNPs encapsulated in chitosan nanoparticles were rolled up to form a tubular nerve conduit. Then, the fibrin gel was loaded with r-ADSCs and injected into the lumen of the PLGA conduit implanted into the 10 mm transected sciatic nerve rat model. The assessment of sciatic nerve regeneration was performed by immunohistochemistry staining, histological and behavioral tests after 3 months post-surgery. The schematic image shown is the authors’ work