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Fig. 7 | BMC Neuroscience

Fig. 7

From: Epileptiform activity in mouse hippocampal slices induced by moderate changes in extracellular Mg2+, Ca2+, and K+

Fig. 7

Effects of adding extra 0.5 mM Mg2+ on hippocampal epileptiform activities. Data collected from two thick hippocampal slices of two young mice. Extracellular filed potentials recorded simultaneously from CA3 and CA1 areas and during perfusion with moderately modified (m)ACSF. Extra 0.5 mM Mg2+ added in mACSF and application times denoted by solid lines above traces. Original signals in A and D illustrated after treatment with a band-pass filter (2–500 Hz). Arrowed events in B, C and E, F expanded in a wide frequency band (0–1000 Hz). Note that adding extra 0.5 mM Mg2+ in mACSF suppressed ictal discharges (A, C) or reduced discharge durations (D, F)

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