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Fig. 6 | BMC Neuroscience

Fig. 6

From: Epileptiform activity in mouse hippocampal slices induced by moderate changes in extracellular Mg2+, Ca2+, and K+

Fig. 6

Effects of glutamate receptor antagonists on hippocampal epileptiform activates. Extracellular field potentials recorded from three thick slices of two young mice. Traces collected following slice perfusion with moderately modified (m)ACSF. CNQX, AP5 and MK8-1 added in mACSF at indicated concentrations, and application times indicated by solid lines above traces. A Field potentials recorded before and following CNQX application and illustrated after treatment with a band-pass filter (2–500 Hz). B, C Arrowed events expanded in a wide frequency band (0–1000 Hz). D–F and G–I Field potentials recorded before and following AP5 or Mk801 application and similarly illustrated as above. Note discharges with the hypersynchronous onset in B and H and discharges without an evident component of the hypersynchronous onset in E, F

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