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Fig. 3 | BMC Neuroscience

Fig. 3

From: In vivo oxygen measurement in cerebrospinal fluid of pigs to determine physiologic and pathophysiologic oxygen values during CNS infections

Fig. 3

Dissolved oxygen in CSF is immediately influenced by the death of the pig. All data presented in this graph were collected in pigs under isoflurane anesthesia. The needle for measuring oxygen inside the CSF was permanently fixed as described in Fig. 2. All data present the oxygen value after a two-step equilibration. The oxygen mmHg was calculated based on the rectal temperature and the current air pressure and pressure inside the CSF compartment. a The heart rate of the pig was continuously measured. The oxygen inside the CSF compartment was measured at each dot with freshly drawn CSF. After the pig had been euthanized (0 min), the oxygen inside the CSF rapidly decreased (n = 1). b The oxygen inside the CSF significantly decreased 10 min post mortem compared to a value determined some minutes before the pig was euthanized (19 h post infection (p.i.)). Each symbol represents one pig. Filled symbols represent infected pigs, unfilled symbols represent uninfected pigs. Error bars are presented with ± SD (n = 6, paired, one-tailed Student’s t-Test, P < 0.0001). c A hyper-oxygenation of the pig over a 30-min period did not increase the oxygen level inside the CSF, whereas inside the blood, an increase was detectable (n = 1)

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