Fig. 4
From: Memantine ameliorates cognitive deficit in AD mice via enhancement of entorhinal–CA1 projection
Memantine attenuated the decreased PPR of the EC–CA1 pathway in APP/PS1 mice. A Representative injection site of AAV-ChR2-EGFP in EC area and a representative trace of blue light-evoked action potentials during whole-cell recording. Scale bar: 1 mm. Vertical bar, 10 mV; horizontal bar, 100 ms. B Representative traces of oEPSCs upon paired light stimulations with 50 ms intervals. C PPR with 50 ms intervals of WT + Saline, APP/PS1 + Saline, APP/PS1 + Memantine mice. n = 15 neurons (from 3–4 mice) for respective groups, respectively. ∗ p < 0.05 compared with WT mice; #p < 0.05 compared with saline treated APP/PS1 mice. Bonferroni’s post hoc test following one-way ANOVA. Data are shown as mean ± SEM