Fig. 3
From: Memantine ameliorates cognitive deficit in AD mice via enhancement of entorhinal–CA1 projection
Memantine improved the dendritic spines of EC neurons projecting to CA1 in APP/PS1 mice. A Representative spine morphology of EC neurons in WT + Saline, APP/PS1 + Saline, APP/PS1 + Memantine mice. Scale bar: 5 μm. B Quantification of the densities for total spines. n = 15–20 neurons (from 3–5 mice) for respective groups, respectively. ∗ p < 0.05 compared with WT mice; #p < 0.05 compared with saline treated APP/PS1 mice. Bonferroni’s post hoc test following one-way ANOVA. Data are shown as mean ± SEM