Fig. 2From: Brain size reductions associated with endothelin B receptor mutation, a cause of Hirschsprung’s diseaseETB−/− rat has a grossly normal intracranial morphology. A, and B represented respective parasagittal micro-CT views of intracranial morphology and isolated brain of sl/sl (ETB−/−) rat. A demonstrated the presence of major craniofacial features and neural structures as labelled. B illustrated magnified micro-CT view of the ETB−/− brain with additional details, which were also presented in the micro-CT scans of wildtype (ETB+/+) rat, C. Lastly, H&E micrograph of the micro-CT scanned sl/sl rat brain confirmed the presence of the identified structures, D. The anatomical features identified were labelled as follows: Acb accumbens nucleus, AO anterior olfactory bulb, apons anterior pons, CA1 CA1 field of hippocampus, CA3 CA3 field of hippocampus, CER cerebellum, Cpu caudate putamen, FrCtx frontal cortex, Hypo hypothalamus, IC inferior colliculus, med medulla, Pit pituitary gland, PTh posterior thalamus, SC superior colliculus, Th thalamus, U. Inc upper incisor, Tong tongue, Trac trachea, Epi epiglottis, H. b hyoid bone, H. palate hard palate, L. Inc lower incisor, NasCa nasal cavity, Nasop nasopharynx, Orop oropharynxBack to article page