Fig. 1
Homozygous ETB mutation was associated with reductions in bodyweight (A) and bodyweight growth rate (B). sl/sl (ETB−/−) rat has a significantly lower bodyweight than that of the control group (ETB+/+ & ETB+/−), 11.40 g versus 13.26 g (df = 9, t-value = 2.51, p-value = 0.03), A. A similar but smaller difference was observed in the comparison of body growth rate, 0.137 g/Hr versus 0.142 g/Hr (df = 9, t-value = 0.58, p-value = 0.58), B. This suggested sl/sl rat was likely to have a proportional organ size shrinkage; furthermore, reduced body growth rate suggested developmental impairment may continue to worsen until maturity. *statistically significant, p-value ≤ 0.05