Fig. 2

Anxiety-related behavior and locomotor activity in the OFT and the EPM. SB-3CT and vehicle-treated E4FAD mice were tested using A, B, C the OFT and D, E, F, the EPM. A For the OFT, the duration spent in the outer, middle and center areas of the circular arena was measured along with B the total distance travelled and C the average velocity. D For the EPM, the duration spent in the closed and open arms was measured together with E the total distance travelled and F the average velocity. Animals were approximately 5 months of age and values represent mean ± SEM (N = 14, 5 males, 9 females for each group). Statistical significance was determined by A, D ANOVA followed by the BKY procedure and B, C, E, F an unpaired t-test. *p < 0.05. EPM Elevated plus maze, OFT Open field test, E4FAD Apolipoprotein E4 x Familial Alzheimer’s disease, SEM Standard error of the mean, ANOVA Analysis of variance, BKY Benjamini, Krieger, and Yekutieli