Skip to main content
Fig. 12 | BMC Neuroscience

Fig. 12

From: MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease

Fig. 12

Testing spatial memory using the RAWM. Wild type, 5xFAD, 5xFAD/MMP9KO and MMP9KO mice were tested for their ability to find the hidden platform in the RAWM. A A schematic of the maze layout is displayed. Mice were tested in nine trials per day for 5 days. B The number of incorrect entries made and C the time taken to find the maze were recorded and analyzed. D The total distance travelled per trial and E the average velocity while swimming were also evaluated. Animals were approximately 6 months of age and values represent mean ± SEM (N = 12, 6 males, 6 females for each group). No statistical significance was identified in any of the parameters by ANOVA. RAWM Radial arm water maze, WT Wild-type, MMP Matrix metallopeptidase, FAD Familial Alzheimer’s disease, MMP9KO MMP9 knockout, SEM Standard error of the mean, ANOVA Analysis of variance

Back to article page